Napoleon Lafayette Murrell born September 25, 1859 in Kentucky and married Nannie Massey Snyder born January 11, 1870. Murrell was a book salesman for the Methodist Publishing Company and met Nannie Snyder when he stayed at Snyder House in Elizabethton. There were three children born to the union, Orin Roger Murrell (died at two years of age of meningitis), Hugh Loftus Murrell (born February 14, 1893), and Pauline Murrell Stone (born February 25, 1908).
In 1897, the Murrells leased the Cloudland Hotel on Roan Mountain and ran the hotel for ten summers. The Murrells ran the Lynnwood Hotel in Elizabethton from 1907-1909. They then leased and operated the Colonial Hotel in Johnson City, Tennessee from the St. John family from 1910-1920. The Colonial Hotel contained 166 rooms with 132 rooms being bedrooms. In 1920, they left Johnson City and went to Unaka for six months, then left to run Hotel Marion in Marion, Virginia.